Basic Mechanisms in the Healing Cutaneous Wound

Basic mechanisms in the healing cutaneous wound.

The process of wound healing can be divided into substrate, proliferative, and remodeling phases. The basic biologic and physiologic events which transpire during these stages are examined in detail. Particular emphasis is placed on the interactions between platelets, macrophages, and other inflammatory cells, and fibroblasts in the healing wound. Recent advances in the roles played by interleu...

Cutaneous wound healing

Chemokines in cutaneous wound healing.

Healing of wounds is one of the most complex biological events after birth as a result of the interplay of different tissue structures and a large number of resident and infiltrating cell types. The latter are mainly constituted by leukocyte subsets (neutrophils, macrophages, mast cells, and lymphocytes), which sequentially infiltrate the wound site and serve as immunological effector cells but...

Mast Cells in Cutaneous Wound Healing

Mast cells are suggested to participate in wound healing, but their specific role has remained obscure. Mast cells are a rich source of inflammatory mediators, such as histamine, proteoglycans, the proteases tryptase and chymase, lipids, growth factors and cytokines. Among these mediators, there are many that have effects on cell growth, tissue turnover and repair. The aim of this study was to ...

Stem Cells for Cutaneous Wound Healing

Optimum healing of a cutaneous wound involves a well-orchestrated cascade of biological and molecular processes involving cell migration, proliferation, extracellular matrix deposition, and remodelling. When the normal biological process fails for any reason, this healing process can stall resulting in chronic wounds. Wounds are a growing clinical burden on healthcare systems and with an aging ...